Oxycontin
$350.00
Description
OxyContin, a trade name for the narcotic oxycodone hydrochloride, is a painkiller available in the United States only by prescription. OxyContin is legitimately prescribed for relief of moderate to severe pain resulting from injuries, bursitis, neuralgia, arthritis, and cancer. .
Oxycodone, sold under the brand name Roxicodone and OxyContin(which is the extended-release form) among others, is a semi-synthetic opioid used medically for the treatment of moderate to severe pain. It is highly addictive[14] and is a commonly abused drug.[15][16] It is usually taken by mouth, and is available in immediate-releaseand controlled-release formulations.[15]Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation.[15] In the United Kingdom, it is available by injection.[17] Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, naltrexone, and aspirin.[15]
 |
|
 |
|
| Clinical data | |
|---|---|
| Pronunciation | /ɒksiˈkoʊdoʊn/ |
| Trade names | Roxicodone, OxyContin, others |
| Other names | Eukodal, eucodal; dihydrohydroxycodeinone, 7,8-dihydro-14-hydroxycodeinone, 6-deoxy-7,8-dihydro-14-hydroxy-3-O-methyl-6-oxomorphine[1] |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682132 |
| License data | |
| Pregnancy category |
|
| Dependence liability |
High[3] |
| Addiction liability |
High[4] |
| Routes of administration |
By mouth, sublingual, intramuscular, intravenous, intranasal, subcutaneous, transdermal, rectal, epidural[5] |
| Drug class | Opioid |
| ATC code | |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | By mouth: 60–87%[7][8] |
| Protein binding | 45%[7] |
| Metabolism | Liver: mainly CYP3A, and, to a much lesser extent, CYP2D6 (~5%);[7]95% metabolized (i.e., 5% excreted unchanged)[10] |
| Metabolites | • Noroxycodone(25%)[9][10] • Noroxymorphone(15%, free and conjugated)[9][10] • Oxymorphone(11%, conjugated)[9][10] • Others (e.g., minor metabolites)[10] |
| Onset of action | IRTooltip Instant release: 10–30 minutes[8][10] CRTooltip controlled release: 1 hour[11] |
| Elimination half-life | IR: 2–3 hours[10][8] CR: 4.5 hours[12] |
| Duration of action | IR: 3–6 hours[10] CR: 10–12 hours[13] |
| Excretion | Urine (83%)[7] |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.000.874 |
| Chemical and physical data | |
| Formula | C18H21NO4 |
| Molar mass | 315.369 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 219 °C (426 °F) |
| Solubility in water | 166 (HCl) |
| (verify) | |
Common side effects include euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating.[15] Side effects may also include addiction and dependence, substance abuse, irritability, depression or mania, delirium, hallucinations, hypoventilation, gastroparesis, bradycardia, and hypotension.[15] Those allergic to codeine may also be allergic to oxycodone.[15] Use of oxycodone in early pregnancy appears relatively safe.[15] Opioid withdrawal may occur if rapidly stopped.[15] Oxycodone acts by activating the μ-opioid receptor.[18]When taken by mouth, it has roughly 1.5 times the effect of the equivalent amount of morphine.[19]
Oxycodone was originally produced from the opium poppy opiate alkaloid thebaine in 1916 in Germany. One year later, it was used medically for the first time in Germany in 1917.[20] It is on the World Health Organization’s List of Essential Medicines.[21] It is available as a generic medication.[15] In 2022, it was the 60th most commonly prescribed medication in the United States, with more than 11 million prescriptions.[22][23] A number of abuse-deterrent formulations are available, such as in combination with naloxone or naltrexone.[16][24]
Medical uses
Side effects
Overdose
Interactions
Pharmacology
Chemistry
History
Society and culture
References
Further reading
External links
Arlen P –
After years of dealing with nerve pain, OxyContin is the only thing that truly helps. The relief is consistent and the delivery was discreet and fast.
Maila D –
Excellent service. My prescription was handled professionally and arrived within two days. OxyContin helps me get through the day without constant pain.
Aberdeen –
Chronic back pain used to ruin my sleep. This gives me the relief I need to function. Delivery was secure and packaging was subtle.
Ronan –
I’ve tried everything for my arthritis, but only OxyContin brings me full relief. Service was prompt, and I appreciated the follow-up support
Zayven –
Effective for long-term injury recovery. Pain levels are finally under control. Easy to order and arrived earlier than expected.
Daxon –
The only medication that keeps my pain from surgery in check. Delivery came quickly with clear instructions. Thank you.
Milton keynes –
Was worried about getting my prescription filled smoothly, but everything went perfectly. Medication works well and lasts as expected.
Elani –
OxyContin helps manage my pain with fewer doses. Ordering online was straightforward, and they were very professional throughout.
K Sunderland –
I suffer from post-accident trauma pain, and this gives me real relief. Very reliable delivery service—never late.
Liora –
I was treated with respect throughout the process. OxyContin is strong but effective when taken as prescribed. Highly recommended for chronic pain sufferers.
Hunter –
OxyContin managed my post-surgery pain effectively. It gave me the relief I needed while I recovered.
Paula Jones –
OxyContin finally took away my back pain
Christopher –
Excellent service
Fast and reliable